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Regioselective synthesis of deuterated analogs of the neurotoxin MPTP

✍ Scribed by Stéphane Mabic; Neal Castagnoli Jr.

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
312 KB
Volume
38
Category
Article
ISSN
0022-2135

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✦ Synopsis

1 -Methyl-4-phenyl-2-pyridone has been used as starting material for the efficient and regioselective synthesis of deuterated analogues of the neurotoxin 1 -methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP). MPTP-2,242, MPTP-6,6-& and MPTP-2,2,6,6-d4 were obtained in good yield through a combination of alkaline deuterium exchange and selective LiAIH4 and LiAID4 reduction reactions.

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