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Synthesis of Racemic Tricyclic 1,2,4-Trioxanes that Are Isomeric to Simplified Analogues of Naturally Occurring Artemisinin.

✍ Scribed by M. Yu. Krasavin; M. V. Dorogov

Publisher: John Wiley and Sons
Year: 2005
Weight: 14 KB
Volume: 36
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200523230

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✦ Synopsis

Other bioactive products U 1300 Synthesis of Racemic Tricyclic 1,2,4-Trioxanes that Are Isomeric to Simplified Analogues of Naturally Occurring Artemisinin. -Key step is the cyclization of a ketone-tethered enol ether to give the novel trioxane framework (II)/(III), simplified analogue of an artemisinin isomer with potential antimalarial activity. -(KRASAVIN, M. Y.

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