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Synthesis of racemic and chiral codeine and morphine via the dihydrothebainones. (Chemistry of opium alkaloids, Part XI)

โœ Scribed by T. S. Lie; L. Maat; H. C. Beyerman


Book ID
104588143
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
255 KB
Volume
98
Category
Article
ISSN
0165-0513

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Synthesis and preliminary pharmacology*
โœ J. T. M. Linders; T. S. Lie; L. Maat ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Wiley (John Wiley & Sons) โš– 197 KB ๐Ÿ‘ 1 views

The synthesis of 4,5orepoxy-a,a,l7-trimethyl-6a,14orethenoisomorphinan-7ormethanol (5) via hydrogenolysis of the corresponding 3-(l-phenyltetrazol-5-yl) ether (2) is described. The etheno bridge was retained under the conditions used. Preliminary pharmacology of the title compound showed strong anal