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Synthesis of 7,8-Didehydro-3,4-Dimethoxy-17-Methylmorphinan-6-one and the Regioselective Reduction of the Keto Function (Chemistry of Opium Alkaloids, Part XXIV)

โœ Scribed by R. A. van Gurp; T. S. Lie; C. Mense; L. Maat


Publisher
Wiley (John Wiley & Sons)
Year
2010
Weight
214 KB
Volume
96
Category
Article
ISSN
0037-9646

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Synthesis and preliminary pharmacology*
โœ J. T. M. Linders; T. S. Lie; L. Maat ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Wiley (John Wiley & Sons) โš– 197 KB ๐Ÿ‘ 1 views

The synthesis of 4,5orepoxy-a,a,l7-trimethyl-6a,14orethenoisomorphinan-7ormethanol (5) via hydrogenolysis of the corresponding 3-(l-phenyltetrazol-5-yl) ether (2) is described. The etheno bridge was retained under the conditions used. Preliminary pharmacology of the title compound showed strong anal