✦ LIBER ✦
Synthesis and preliminary pharmacology* of the rigid dehydroxylated etorphine analogue 4,5α-epoxy-α,α,17-trimethyl-6α,14α-etheno-isomorphinan-7α-methanol (chemistry of opium alkaloids, part XXVI**)
✍ Scribed by J. T. M. Linders; T. S. Lie; L. Maat
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2010
- Weight
- 197 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0037-9646
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✦ Synopsis
The synthesis of 4,5orepoxy-a,a,l7-trimethyl-6a,14orethenoisomorphinan-7ormethanol (5) via hydrogenolysis of the corresponding 3-(l-phenyltetrazol-5-yl) ether (2) is described. The etheno bridge was retained under the conditions used. Preliminary pharmacology of the title compound showed strong analgesic potency.