𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 6, 14-ethenoisomorphinans and 6, 14-ethenomorphinans based on Diels-Alder adducts of 6-demethoxythebaine and 6-demethoxy-β-dihydrothebaine; pharmacology of the isomorphinans (Chemistry of Opium Alkaloids, Part XIX)

✍ Scribed by P. R. Crabbendam; T. S. Lie; J. T. M. Linders; L. Maat


Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
605 KB
Volume
103
Category
Article
ISSN
0165-0513

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Synthesis of 7-substituted 6-demethoxyth
✍ R. H. Woudenberg; G. J. Meuzelaar; L. Maat 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 730 KB

## Abstract Mesylation of 7‐acetoxyneopine (4), followed by reductive cleavage of the acetyl group gave 6α‐__O__‐mesyl‐7α‐hydroxyneopine (6), in which the hydroxyl group was protected as a methoxymethoxy group. Elimination of the mesyl ester yielded 7‐(methoxymethoxy)‐6‐demethoxythebaine (7). For t