The syntheses of nitroxyl oxirane and further functionalized derivatives are described. Ring-cleavage reactions of this epoxide have been carried out with a variety of nucleophiles in order to show the general synthetic utility for preparing nitroxyls bearing two functional groups. The relatively fa
Synthesis of pyrrolidines by intramolecular carbanionic epoxide opening
โ Scribed by Roland Achini; Wolfgang Oppolzer
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 215 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0040-4039
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## Abstract Carbanions of 3โchloropropyl phenyl sulfones containing electrophilic groups such as carbonyl and imino groups in the __ortho__ position of the phenyl ring add intramolecularly to these groups to give aldolโtype anions. These anions undergo intramolecular 1,5โsubstitution of chlorine to
By reaction of 1,2-anhydro-5-O-acetyl-3-O-benzyl-~-D-carbaxylofuranose 8 with the aglycone in alkaline medium followed by deprotection carbanucleosides 10 were obtained. Carbocyclic nucleosides are of relevance due to their antiviral and anticancer properties1 as well as their high bioavailability s