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General synthesis of carbanucleosides via regiospecific epoxide opening by the aglycone

โœ Scribed by Harald Baumgartner; Christoph Marschner; Rainer Pucher; Herfried Griengl

Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
227 KB
Volume
32
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

By reaction of 1,2-anhydro-5-O-acetyl-3-O-benzyl-~-D-carbaxylofuranose 8 with the aglycone in alkaline medium followed by deprotection carbanucleosides 10 were obtained. Carbocyclic nucleosides are of relevance due to their antiviral and anticancer properties1 as well as their high bioavailability since no hydrolizeable N-acetal bond

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