Synthesis of pyrimido[4,5-e][1,4]oxazepin-5-ones
✍ Scribed by Arthur A. Santilli; Dong Han Kim; Stephen V. Wanser
- Book ID
- 112122628
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1972
- Tongue
- English
- Weight
- 343 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0022-152X
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## Abstract A new method was developed for the synthesis of 6,7‐dihydro‐5__H__‐pyrimido[4,5‐__e__][1,4]diazepin‐8(9__H__)‐one derivatives. The key to construct the pyrimido[4,5‐__e__][1,4]diazepine core is the intramolecular amidation of __N__‐((4‐amino‐6‐chloropyrimidin‐5‐yl)methyl)‐substituted am
## Abstract magnified image Novel 11‐amino‐6‐aryl‐6,7‐dihydroindeno[1,2‐__e__] pyrimido[4,5‐__b__][1,4]diazepin‐5(5a__H__)‐ones 4a‐f were prepared regioselectively by the tricomponent reaction of 4,5,6‐triaminopyrimidine 1, 1,3‐indandione 2 and aromatic aldehydes 3a‐f. The bicomponent approach, us