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Pyrimido[4,5-e][1,4] diazepin-5-ones and 4,4-ethylenediaminobis(2-phenyl-pyrimidine-5-carboxylic acid) diethyl esters

✍ Scribed by Kim, Dong Han; Santilli, Arthur A.


Book ID
121382084
Publisher
American Chemical Society
Year
1969
Tongue
English
Weight
234 KB
Volume
12
Category
Article
ISSN
0022-2623

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## Abstract A new method was developed for the synthesis of 6,7‐dihydro‐5__H__‐pyrimido[4,5‐__e__][1,4]diazepin‐8(9__H__)‐one derivatives. The key to construct the pyrimido[4,5‐__e__][1,4]diazepine core is the intramolecular amidation of __N__‐((4‐amino‐6‐chloropyrimidin‐5‐yl)methyl)‐substituted am