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Synthesis of protected, chiral α,α-disubstituted α-amino acids via a Beckmann rearrangement

✍ Scribed by Rogelio P. Frutos; Denice M. Spero

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
202 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of chiral, nonracemic, fully protected a,a-disubstituted a-amino acids via the Beckmann rearrangement of tosylated oximes 1 is described. The desired amino acids were obtained in good yields with excellent enantioseleetivities in relatively few steps.

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