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Asymmetric synthesis of α,α-disubstituted α-amino acid derivatives using MABR promoted rearrangement

✍ Scribed by Masayuki Matsushita; Hana Maeda; Mitsuaki Kodama

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
211 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient route for the asymmetric synthesis of ct,a-disubstituted or-amino acids derivatives (1, 2, and 3) starting from readily available epoxy silyl ethers (6) has been developed. High enantiomeric purity can be realized by the present method using a combination of MABR rearrangement of a chiral epoxide and Curtius rearrangement.

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