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Efficient, practical synthesis of symmetrically α,α-disubstituted α-amino acids

✍ Scribed by Trevor K. Ellis; Collin H. Martin; Hisanori Ueki; Vadim A. Soloshonok


Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
121 KB
Volume
44
Category
Article
ISSN
0040-4039

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Catalytic, asymmetric synthesis of α,α-d
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Copper(salen) complex 1 has been found to catalyse the asymmetric alkylation of enolates derived from a variety of amino acids. There is a clear relationship between the size of the side chain in the substrate and the enantioselectivity of the process, so that the enantioselectivity decreases in the