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Synthesis of possible metabolites of chlorpromazine. III. 7,8-Disubstituted chlorpromazine derivatives

โœ Scribed by Edward A. Nodiff; Keiichi Tanabe; Franz Schnierle; Shiro Morosawa; Thomas W. Hoffman; Katsuhiko Takeda; Albert A. Manian


Book ID
112122091
Publisher
Journal of Heterocyclic Chemistry
Year
1970
Tongue
English
Weight
455 KB
Volume
7
Category
Article
ISSN
0022-152X

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The eyntheeie of 2-chloro-10-(3'-dimethylaminopropyl)phenothiazine-3', 3'-d2 (Chlorpromazine-d2) and ite four major metabolitee (the mono-and didemethylated aminee, chlorpromazine sulfoxide, and chlorpromazine N-oxide), all containing the 3',3'-d2 label in > 95% ieotopic purity, ie deecribed. Consid