The eyntheeie of 2-chloro-10-(3'-dimethylaminopropyl)phenothiazine-3', 3'-d2 (Chlorpromazine-d2) and ite four major metabolitee (the mono-and didemethylated aminee, chlorpromazine sulfoxide, and chlorpromazine N-oxide), all containing the 3',3'-d2 label in > 95% ieotopic purity, ie deecribed. Consid
Pharmacology of mono- and disubstituted chlorpromazine metabolites
โ Scribed by Joseph P. Buckley; Marie L. Steenberg; Herbert Barry Iii; Albert A. Manian
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- English
- Weight
- 596 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0022-3549
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Conditions have been established for the quantitative formation of radiolabeled derivatives of chlorpromazine, chlorpromazine sulfoxide and their demethylated analogs in plasma extracts. Tritiated N-acetyl derivatives are formed from the demethylated compounds and C14-quatcrnary amines from the ter
Ultraviolet absorption and attenuated total reflectance infrared spectra of chlorpromazine and 14 possible metabolites have been recorded and analyzed. Structural correlations of the absorption bands are presented and discussed. This collection provides a positive means of identifying chlorpromazine