The eyntheeie of 2-chloro-10-(3'-dimethylaminopropyl)phenothiazine-3', 3'-d2 (Chlorpromazine-d2) and ite four major metabolitee (the mono-and didemethylated aminee, chlorpromazine sulfoxide, and chlorpromazine N-oxide), all containing the 3',3'-d2 label in > 95% ieotopic purity, ie deecribed. Consid
Oxidative reactions of hydroxylated chlorpromazine metabolites
β Scribed by Richard L. McCreery
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 535 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3549
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Conditions have been established for the quantitative formation of radiolabeled derivatives of chlorpromazine, chlorpromazine sulfoxide and their demethylated analogs in plasma extracts. Tritiated N-acetyl derivatives are formed from the demethylated compounds and C14-quatcrnary amines from the ter
A calorimetric method is described which can be used for the routine determination of primary and secondary IV-hydroxylamino compounds in drug metabolism studies using microsomal preparations. The assay is carried out on the supernatant obtained after protein precipitation of the incubation mixture.