✦ LIBER ✦

Synthesis of piperidine analogs of 1-(3-chlorophenyl)piperazine, a well known serotonin ligand

✍ Scribed by Stanislav Rádl; Petr Hezký; Jan Taimr; Jan Proška; Ivan Krejčí

Publisher: Journal of Heterocyclic Chemistry
Year: 1999
Tongue: English
Weight: 469 KB
Volume: 36
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570360431

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Synthesis of arylpiperideines 3a‐3d and arylpiperidines 4a‐4d as analogs of a well known serotonin ligand 1‐(3‐chlorophenyl)piperazine is reported. Starting aryllithium derivatives were treated with 1‐methyl‐piperdin‐4‐one to provide the corresponding hydroxy derivatives 6a and 6b. N‐Methylpiperideine derivatives 3a and 3c were obtained by their dehydration while the corresponding N‐unsubstituted compounds 3b and 3d were prepared indirectly by a three‐step procedure. Hydrogenation of piperideine 3a provided the corresponding piperidine derivative 4a which after demethylation yielded 4b. Similar 4‐pyridyl derivatives 4c and 4d were prepared by a similar strategy via the corresponding methoxy derivatives.

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis of Piperi

ChemInform Abstract: Synthesis of Piperidine Analogues of 1-(3-Chlorophenyl)piperazine, a Well Known Serotonin Ligand.

✍ Stanislav Radl; Petr Hezky; Jan Taimr; Jan Proska; Ivan Krejci 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB

Synthesis of [O-Methyl-11C] 1-(2-chlorop

Synthesis of [O-Methyl-11C] 1-(2-chlorophenyl)-5- (4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic Acid Piperidin-1-ylamide: A Potential PET Ligand for CB1 Receptors.

✍ J. S. Dileep Kumar; Jaya Prabhakaran; Victoria Arango; Ramin V. Parsey; Mark D. 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 92 KB 👁 1 views

Microwave Assisted Synthesis of 2-(4-Sub

Microwave Assisted Synthesis of 2-(4-Substituted piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile as a New Class of Serotonin 5-HT3 Receptor Antagonists.

✍ Radhakrishnan Mahesh; Ramachandran Venkatesha Perumal; Pandi Vijaya Pandi 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 18 KB 👁 1 views

Synthesis of [2-{(4-chlorophenyl) (4-[12

Synthesis of [2-{(4-chlorophenyl) (4-[125I]iodophenyl)} methoxyethyl]-1-piperidine-3-carboxylic acid, [125I]CIPCA: A potential radiotracer for GABA uptake sites

✍ Marcian E. Van Dort; David L. Gildersleeve; Donald M. Wieland 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 491 KB

## Abstract The synthesis of racemic [2‐{(4‐Chlorophenyl) (4‐iodophenyl)} methoxyethyl]‐1‐piperidine‐3‐carboxylic acid, (CIPCA) and its radioiodinated analog [^125ß^I]CIPCA is described. CIPCA was synthesized from 4‐iodobenzoyl chloride in five steps in 16% overall yield. Ammonium sulfate catalyzed

Synthesis of N1-3-[18F]fluoropropyl-N4-2

Synthesis of N1-3-[18F]fluoropropyl-N4-2-([3,4-dichlorophenyl]ethyl)piperazine, a high affinity ligand for sigma receptor

✍ Dale O. Kiesewetter; Brian de Costa 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 275 KB

## Abstract The radiochemical synthesis of the high affinity, selective sigma receptor ligand, N^1^‐3‐[^18^F]Fluoropropyl‐N^4^‐2‐([3,4‐dichlorophenyl]ethyl)piperazine, is reported. The labeled compound is prepared by fluoride displacement on a bismethanesulfonate salt of the propyl methanesulfonylo

Synthesis of tritiated 1-[2-(diphenylmet

Synthesis of tritiated 1-[2-(diphenylmethoxy)ethyl]-4-[3-(3-azidophenyl)propyl]piperazine ([3H]-meta azido GBR-12935), a photoaffinity ligand for the dopamine reuptake site

✍ A. Thurkauf; B. de Costa; P. Berger; S. Paul; K. C. Rice 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 201 KB

A tritiated photoaffinity ligand for the dopamine reuptake transporter protein, 1-[2-(diphenylmethoxy) ethyl] -4-[ 3-(3 -azidophenyl)-2,3-ditritiopropyl]piperazine, of specific activity 41.8 Cilmmol, was prepared in six steps starting from 1-[2-(diphenylmethoxy)ethyl] piperazine.