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ChemInform Abstract: Synthesis of Piperidine Analogues of 1-(3-Chlorophenyl)piperazine, a Well Known Serotonin Ligand.

✍ Scribed by Stanislav Radl; Petr Hezky; Jan Taimr; Jan Proska; Ivan Krejci


Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
31
Category
Article
ISSN
0931-7597

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Synthesis of piperidine analogs of 1-(3-
✍ Stanislav RΓ‘dl; Petr HezkΓ½; Jan Taimr; Jan ProΕ‘ka; Ivan Krejčí πŸ“‚ Article πŸ“… 1999 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 469 KB

## Abstract Synthesis of arylpiperideines 3a‐3d and arylpiperidines 4a‐4d as analogs of a well known serotonin ligand 1‐(3‐chlorophenyl)piperazine is reported. Starting aryllithium derivatives were treated with 1‐methyl‐piperdin‐4‐one to provide the corresponding hydroxy derivatives 6a and 6b. __N_