Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase
✍ Scribed by Robert A. Mook Jr.; Karen Lackey; Chad Bennett
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 178 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
This paper describes the rational design and synthesis of novel inhibitors of human steroid 5a-reductase. Steroidal nitrones were synthesised via an eight-step sequence from epiandrosterone and were tested for activity against type I and II 5a-reductase isozymes. Judicious placement of the nitrone i
## Abstract 17β‐[N‐(1,1‐Dimethylethyl)carbamoyl]androsta‐3,5‐diene‐4‐^14^C‐3‐carboxylic acid ([^14^C]SK&F 105657) was prepared __via__ a three‐step sequence (t‐butyl amidation, triflation and carbomethoxylation) starting from androst‐4‐en‐3‐one‐4‐^14^C‐17β‐carboxylic acid. Its A‐ring aromatic analo
Pyrrolebutyric Acid Derivatives as Inhibitors of Steroid 5α-Reductase. -A series of pyrrolebutyric acid derivatives (I) (37 examples) are synthesized and evaluated for their inhibitory activity on steroid 5α-reductase in vitro and ex vivo. The calcium salt of (Id) shows potent inhibitory activities