𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of carbon-14 and tritiated steroidal 5α-reductase inhibitors

✍ Scribed by Arthur Y. L. Shu; J. Richard Heys

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
414 KB
Volume
34
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

17β‐[N‐(1,1‐Dimethylethyl)carbamoyl]androsta‐3,5‐diene‐4‐^14^C‐3‐carboxylic acid ([^14^C]SK&F 105657) was prepared via a three‐step sequence (t‐butyl amidation, triflation and carbomethoxylation) starting from androst‐4‐en‐3‐one‐4‐^14^C‐17β‐carboxylic acid. Its A‐ring aromatic analog 17β‐[N‐(1,1‐dimethylethyl)carbamoyl]estra‐1,3,5‐(10)‐triene‐3‐carboxylic acid (SK&F 105656) was labeled with tritium by means of iridium‐mediated exchange methodology.

📜 SIMILAR VOLUMES

Steroidal nitrone inhibitors of 5α-reduc
Steroidal nitrone inhibitors of 5α-reductase
✍ Andrea J Robinson; Indawati DeLucca; Spencer Drummond; George A Boswell 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 106 KB

This paper describes the rational design and synthesis of novel inhibitors of human steroid 5a-reductase. Steroidal nitrones were synthesised via an eight-step sequence from epiandrosterone and were tested for activity against type I and II 5a-reductase isozymes. Judicious placement of the nitrone i

ChemInform Abstract: Steroidal Antiandro
ChemInform Abstract: Steroidal Antiandrogens and 5α-Reductase Inhibitors
✍ Eugene Bratoeff; Elena Ramirez; Eugenia Murillo; Gregoria Flores; Marisa Cabeza 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v