3, -p-carborane-l-yl)propyl]-6-phenyl phenanthridinium chloride hydrochloride (13) has been synthesised by reacting 3,8-diacetamido-6-phenylphenanthridine ) in nitrobenzene at 120°C for 4 days and subsequent removal of the protective groups using 33% HBr/AcOH. Conversion to the chloride hydrochlori
✦ LIBER ✦
Synthesis of para- and nido-carboranyl phenanthridinium compounds for neutron capture therapy
✍ Scribed by Werner Tjarks; Hadi Ghaneolhosseini; Cecilia L.A Henssen; Jonas Malmquist; Stefan Sjöberg
- Book ID
- 103414279
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 224 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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Glycosidation of alkynols using the trichloroacetimidate method led to the alkynyl glycosides 2 a,b, 6, 10 and 14 in 53 ± 68 % yield, which by reaction with decaborane( ) afforded the protected peracetylated o-carboranyl glycosides 3 a,b, 7, 11 and 15 in 43 ± 61 % yield. Base-catalyzed solvolysis ga