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Ortho-Carboranyl Glycosides of Glucose, Mannose, Maltose and Lactose for Cancer Treatment by Boron Neutron-Capture Therapy

✍ Scribed by Lutz F. Tietze; Ulrich Bothe

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 118 KB
Volume: 4
Category: Article
ISSN: 0947-6539
DOI: 10.1002/(sici)1521-3765(19980710)4:7<1179::aid-chem1179>3.0.co;2-f

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✦ Synopsis

Glycosidation of alkynols using the trichloroacetimidate method led to the alkynyl glycosides 2 a,b, 6, 10 and 14 in 53 ± 68 % yield, which by reaction with decaborane( ) afforded the protected peracetylated o-carboranyl glycosides 3 a,b, 7, 11 and 15 in 43 ± 61 % yield. Base-catalyzed solvolysis gave the unprotected glycosides 4 a,b, 8, 12 and 16 in 71 ± 97 % yield.

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