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Synthesis of boronated phenanthridinium derivatives for potential use in boron neutron capture therapy (BNCT)

✍ Scribed by Hadi Ghaneolhosseini; Werner Tjarks; Stefan Sjöberg

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
406 KB
Volume
53
Category
Article
ISSN
0040-4020

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✦ Synopsis

3,

-p-carborane-l-yl)propyl]-6-phenyl phenanthridinium chloride hydrochloride (13) has been synthesised by reacting 3,8-diacetamido-6-phenylphenanthridine ) in nitrobenzene at 120°C for 4 days and subsequent removal of the protective groups using 33% HBr/AcOH. Conversion to the chloride hydrochloride was accomplished by the action of hydrochloric acid on the pseudo-base of 13.

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Boronation of antibodies with mercaptoun
Boronation of antibodies with mercaptoundecahydro-closo-dodecaborate(2-) anion for potential use in boron neutron capture therapy
✍ Fazlul Alam; Albert H. Soloway; Rolf F. Barth 📂 Article 📅 1987 🏛 Elsevier Science ⚖ 455 KB

The anionic polyhedral borane derivative, mercaptoundecahydro-closo-dodecaborate(2-), has been evaluated as a boronating agent for antibodies. The objective of these studies was the selective delivery of boron to neoplasms for neutron capture therapy. Incubation of a large excess of this anion with