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Synthesis of P-chiral, phosphorothioic acid analogs of N-phospholeucinamide

✍ Scribed by Charles M. Thompson; Jing Lin

Book ID: 104255898
Publisher: Elsevier Science
Year: 1996
Tongue: French
Weight: 251 KB
Volume: 37
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(96)02107-7

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✦ Synopsis

A diastereomeric mixture of R e-and S e-N-[O-methyl phosphorothioic acid]leucinamides were synthesized by thiophosphorylation of leucinamide followed by monodealkylation of the phosphate methyl ester.

Individual diastereomers were prepared by a scquence utilizing selective protection of the thioic acid moiety as the S-benzyl group, chromatographic separation, and deprotection.

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