Phospholipids chiral at phosphorus. Synthesis and stereospecificity of phosphorothioate analogs of platelet-activating factor
β Scribed by Rosario-Jansen, Theresa; Jiang, Ru Tai; Tsai, Ming Daw; Hanahan, Donald J.
- Book ID
- 127216375
- Publisher
- American Chemical Society
- Year
- 1988
- Tongue
- English
- Weight
- 693 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0006-2960
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π SIMILAR VOLUMES
A novel stereospecific synthesis of biologically active ether-phospholipids is reported. Ether phospholipids are among the most potent biologically active phospholipid derivatives.ls2 Naturally occuring as membrane-components, a number of l-sn-alkoxyglycero-phosphorylcholines have been shown to be r
## 2-Azido-2-deoxy-l-O-hexadecyl-sn-glycero-3-phosphorylcholine was prepared in good yield from D-mannitol via 3-O-hexadecyl-2-O-methanesulfonyl-l-O-triphenylmethyl-sn-glycerol. Nucleophilic displacement of the 2-methanesulfonate function by benzoate or azide ion proceeded with inversion of config