A new method for the stereospecific synthesis of ether phospholipids. Preparation of the amide analog of platelet-activating factor and related derivatives

✍ Scribed by Nizal S Chadrakumar; Joseph Hajdu

• Publisher: Elsevier Science
• Year: 1982
• Tongue: French
• Weight: 216 KB
• Volume: 23
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)87017-3

✦ Synopsis

A novel stereospecific synthesis of biologically active ether-phospholipids is reported. Ether phospholipids are among the most potent biologically active phospholipid derivatives.ls2 Naturally occuring as membrane-components, a number of l-sn-alkoxyglycero-phosphorylcholines have been shown to be required for a series of vitally important physiological processes. 2-4 Specifically, ether phospholipids are involved in platelet-activation,2 they function as vasodilators3 and as chemotactic aqents.4 Added importance has been attributed to these compounds as a result of recent studies demonstrating their selective tumor-cytotoxicity against a number of different cancer ~~11s.~ Elucidation of the specific mechanisms involved in the biological functioning of ether phospholipids is greatly hindered at the present by lack of efficient synthetic methods for the preparation of these compounds? Development of stereospecific syntheses of 1-sn-alkoxyphospholipids that will allow systematic variation of the substituents, with particular emphasis on the critically