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Synthesis of oxazolyl-substituted morpholinium salts

✍ Scribed by John Boulos; Christina Stujenske

Book ID
102345878
Publisher
Journal of Heterocyclic Chemistry
Year
2006
Tongue
English
Weight
184 KB
Volume
43
Category
Article
ISSN
0022-152X

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✦ Synopsis

Morpholinium salts coupled to oxazolyl moieties have been synthesized via nucleophilic substitution of a series of oxazolyl chlorides with morpholine. The oxazole moieties were first synthesized and then coupled with morpholine. The corresponding hydrochloride and methyl iodide salts were obtained, purified, characterized and then tested for muscarinic receptor binding affinity. Biological test results from MDS Pharma Services revealed no significant muscarinic receptor affinity.

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