β Scribed by John Boulos; Jerome Schulman
No coin nor oath required. For personal study only.
Oxazolylβ5β and furanylβ2βsubstituted imidazoles have been synthesized by coupling the two ring systems via the dipolar cycloaddition of tosyl methyl isocyanide to the corresponding oxazolyl and furanyl aldimines in basic media. These substituted oxazolyl and furanylimidazole bases obtained in this manner were then subjected to hydrogen chloride gas and to methyl iodide to form the corresponding hydrochlorides and methyliodides, respectively. All compounds were purified, characterized and then tested for muscarinic binding affinity. Biological test results revealed low muscarinic receptor affinity and selectivity.
π SIMILAR VOLUMES
## Abstract magnified image Furanyl and oxazolyl Nβsubstituted imidazoline salts were prepared by reacting furanyl and oxazolyl esters with ethylenediamine and trimethyl aluminum, followed by the addition of methyl iodide or hydrogen chloride. The piperidinium salts were prepared by treating furan