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Synthesis of optically active bisdifluorocyclopropanes through a chemo-enzymatic reaction strategy

✍ Scribed by Koichi Mitsukura; Satoshi Korekiyo; Toshiyuki Itoh

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 238 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01088-6

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✦ Synopsis

The first synthesis of bisdifluorocyclopropane derivatives has been accomplished via a chemo-enzymatic reaction strategy; (EF or (Z)-3-tributylstannyl-2-propenols were prepared and their conversion led to the (trans, trans)-and (cis, cis)-bisdifluorocyclopropanes. The subsequent lipase-catalyzed reaction efficiently afforded optically active (trans, trans)-2,2,5,5-tetrafluoro-l,6-bis(hydroxymethyl)bicyclopmpane.

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