The first synthesis of bisdifluorocyclopropane derivatives has been accomplished via a chemo-enzymatic reaction strategy; (EF or (Z)-3-tributylstannyl-2-propenols were prepared and their conversion led to the (trans, trans)-and (cis, cis)-bisdifluorocyclopropanes. The subsequent lipase-catalyzed rea
Novel chemo-enzymatic synthesis of optically active platelet activating factor
β Scribed by Atul Kumar; Vinod Bhakuni
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 163 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
This paper describes an enantioselective enzymatic synthesis of biologically active platelet activating factor (PAF) starting from chloropyruvic acid.
Platelet activating factor (PAF), 2-acetyl glyceryl ether phospho-
π SIMILAR VOLUMES
The synthesis of heterocyclic analogues of the platelet activating factor is described. The preparation starts with acylating rac-tetrahydro-l,3-thiazine-4-carboxylic acid ethyl ester, with palmitoyl chloride to form the amide linkage. Following ester reduction, the phosphocholine part is introduced
The synthesis of heterocyclic analogues of the platelet activating factor is described. The preparation starts with acylating rac-tetrahydro-1,3-thiazine-4-carboxylic acid ethyl ester, with palmitoyl chloride to form the amide linkage. Following ester reduction, the phosphocholine part is introduced