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Synthesis of optically active 2,3-dihydrobenzofuran derivatives through a combination strategy of iron(III)-catalyzed reaction and enzymatic reaction

✍ Scribed by Toshiyuki Itoh; Kimio Kawai; Shuichi Hayase; Hiroyuki Ohara


Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
299 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis


Synthesis of optically active 2,3-dihydrofuran derivatives has been accomplished through a combination strategy of ferric ion-catalyzed cycloaddition of styrene derivatives with quinones and following lipase-catalyzed enantioselective acylation.


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The first synthesis of bisdifluorocyclopropane derivatives has been accomplished via a chemo-enzymatic reaction strategy; (EF or (Z)-3-tributylstannyl-2-propenols were prepared and their conversion led to the (trans, trans)-and (cis, cis)-bisdifluorocyclopropanes. The subsequent lipase-catalyzed rea