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Synthesis of Oligonucleotides Containing 3‘-Alkylcarboxylic Acids Using a Palladium Labile Oligonucleotide Solid Phase Synthesis Support

✍ Scribed by Matray, Tracy J.; Yoo, Dong Jin; McMinn, Dustin L.; Greenberg, Marc M.


Book ID
126088170
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
131 KB
Volume
8
Category
Article
ISSN
1043-1802

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Solid phase synthesis of oligonucleotide
✍ Richard Cosstick; Joseph S. Vyle 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 254 KB

Summarv-A 5'-O-monomethoxytritylthymidine-3'-S-thiophosphoramidite (3) has been used to prepare oligodeoxynucleotides containing 3'-thiothymidine on a solid phase support. The intermediate thiophosphites are most efficiently oxidised using tetrabutylammonium periodate. Polynucleotide analogues conta