Solid phase synthesis of oligonucleotide
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Richard Cosstick; Joseph S. Vyle
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Article
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1989
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Elsevier Science
🌐
French
⚖ 254 KB
Summarv-A 5'-O-monomethoxytritylthymidine-3'-S-thiophosphoramidite (3) has been used to prepare oligodeoxynucleotides containing 3'-thiothymidine on a solid phase support. The intermediate thiophosphites are most efficiently oxidised using tetrabutylammonium periodate. Polynucleotide analogues conta