Synthesis of Oligonucleoside Phosphorodithioates by the H-Phosphonothioate Method.
β Scribed by Kazuo Kamaike; Kumi Hirose; Yoshihiro Kayama; Etsuko Kawashima
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 10 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
A novel method for the efficientsynthesis phosphorodithioate DNA using H-phosphonothioate synthons is described. The 5'-DMT-nucleoside H-phosphonothioate monomers were prepared in two high yielding steps from commercially available phosphoramidites. This strategy for the synthesis of Hphosphonothioa
Simple and efficient synthesis of a new H-phosphonothionylating reagent, 9fluorenemethyl H-phosphonothioate, was developed. The synthetic utility of the reagent has been demonstrated in the preparations of nucleoside H-phosphonothioate, nucleoside phosphorothioate, and nucleoside phosphorodithioate