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9-Fluorenemethyl H-phosphonothioate, a versatile reagent for the preparation of H-phosphonothioate, phosphorothioate, and phosphorodithioate monoesters

✍ Scribed by Jadwiga Jankowska; Jacek Cieślak; Adam Kraszewski; Jacek Stawiński

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 268 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)00218-9

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✦ Synopsis

Simple and efficient synthesis of a new H-phosphonothionylating reagent, 9fluorenemethyl H-phosphonothioate, was developed. The synthetic utility of the reagent has been demonstrated in the preparations of nucleoside H-phosphonothioate, nucleoside phosphorothioate, and nucleoside phosphorodithioate monoesters.

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