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Synthesis of oligodeoxynucleotides and oligodeoxynucleotide analogs using phosphoramidite intermediates

โœ Scribed by M.A. Dorman; S.A. Noble; L.J. McBride; M.H. Caruthers

Book ID
107857349
Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
880 KB
Volume
40
Category
Article
ISSN
0040-4020

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## Abstract A convergent, solutionโ€phase synthesis was developed for the bis(methylene) sulfoneโ€bridged oligodeoxynucleotide analogs (SNA) 5โ€ฒโ€d(HOCH~2~โ€Tso~2~Tso~2~Tso~2~Cso~2~Tso~2~Tso~2~Tso~2~Tโ€CH~2~SO$\rm{\_{3}^{-}}$)โ€3โ€ฒ (35b) and 5โ€ฒโ€d(HOCH~2~โ€Tso~2~Tso~2~Tso~2~Tso~2~Tso~2~Tso~2~Tso~2~Tโ€CH~2~SO$