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Phosphoramidite solid-phase synthesis of site-specifically glycosylated oligodeoxynucleotides

✍ Scribed by Kazunori Matsuura; Miki Hibino; Masanori Kataoka; Yoshihiro Hayakawa; Kazukiyo Kobayashi

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
134 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

A galactose-modified deoxyuridine phosphoramidite was synthesized via the Heck reaction and applied to solid-phase synthesis to provide a new type of oligo DNA-galactose conjugates, which maintained stringent base-pairing fidelity for unique DNA sequences.

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