𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Solid-phase synthesis of oligodeoxynucleotides containing 4-alkoxythymidine residues

✍ Scribed by H. C. P. F. Roelen; H. F. Brugghe; H. van den Elst; G. A. van der Marel; J. H. van Boom

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
647 KB
Volume
111
Category
Article
ISSN
0165-0513

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Immobilized and fully protected oligodeoxynucleotides containing a 4‐(1,2,4‐triazolyl)‐thymidine residue at a predetermined position were prepared according to a well‐established phosphite triester methodology using 2‐cyanoethyl phosphoramidites of a 4‐(1,2,4‐triazolyl)‐substituted thymidine and standard protected nucleosides. Treatment of the immobilized oligomer with methanol, ethanol or n‐propanol in the presence of DBU at 50°C gave the corresponding oligonucleotides containing 4‐methoxy, 4‐ethoxy‐ or 4‐n‐propoxythymidine residue.

📜 SIMILAR VOLUMES

The synthesis of oligodeoxynucleotides c
The synthesis of oligodeoxynucleotides containing 4-thiothymidine residues
✍ Theo T. Nikiforov; Bernard A. Cornolly 📂 Article 📅 1991 🏛 Elsevier Science 🌐 French ⚖ 282 KB

Olgodeoqnucleotides contarnug 4-thothymzdm residues were obtauwdusing the ph~?sphoramtdttes of 2 and J Treatment with CHJOSK tn EtOH was used to rntroduce the I-throketo $mctron at the olqodeoqnucleotrde level. Recently, we have reported the synthesis of 5'-0-(4,4'-dimethoxytrity1)-4-throcyanatothy

Solid-phase synthesis of oligodeoxynucle
Solid-phase synthesis of oligodeoxynucleotides containing 6-O-alkylguanosines
✍ H. C. P. F. Roelen; H. F. Brugghe; H. van den Elst; J. C. Klein; G. A. van der M 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 929 KB

## Abstract High‐quality oligodeoxynucleotides having an 6‐__O__‐alkyl‐2′‐deoxyguanosine (alkyl = methyl, ethyl, __n__‐propyl or __n__‐hexyl) residue at a predetermined position can be obtained via a solid‐phase approach using the respective 2‐cyanoethyl __N,N__‐diisopropylphosphoramidites of 5′‐__

ChemInform Abstract: Solid-Phase Synthes
ChemInform Abstract: Solid-Phase Synthesis of Oligodeoxynucleotides Containing 3′-S-Phosphorothiolate Linkages
✍ Kevin J. Fettes; Ian O'Neil; Stanley M. Roberts; Richard Cosstick 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 25 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Phosphoramidite solid-phase synthesis of
Phosphoramidite solid-phase synthesis of site-specifically glycosylated oligodeoxynucleotides
✍ Kazunori Matsuura; Miki Hibino; Masanori Kataoka; Yoshihiro Hayakawa; Kazukiyo K 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 134 KB

A galactose-modified deoxyuridine phosphoramidite was synthesized via the Heck reaction and applied to solid-phase synthesis to provide a new type of oligo DNA-galactose conjugates, which maintained stringent base-pairing fidelity for unique DNA sequences.