## 04-Protection in thymidine and uridine derivatives has been achieved by the p-nitrophenylethyl group in a silver-ion catalysed alkylation reaction to form valuable building blocks for oligonucleotides syntheses.
Synthesis of O6-p-nitrophenylethyl guanosine and 2′-deoxyguanosine derivatives
✍ Scribed by Thomas Trichtinger; Ramamurthy Charubala; Wolfgang Pfleiderer
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 251 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The synthesis of oligodeoxyribonucleotides on a cross‐linked polystyrene solid support utilizing stable mono‐ and dinucleotide phosphotriester building blocks is presented. The use of __O__^6^[2‐(__p__‐nitrophenyl)ethyl]‐2′‐deoxyguanosine derivatives yields cleaner DNA fragments by supp
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
Trifluoroacetic anhydride at 0" C reacts with a pyridine suspension of deoxyguanosine to generate a polar intermediate, presumably the corresponding 6-pyrldyl derivative. The reaction is complete in less than 15 minutes, and is not accompanied by degradation. From this intermediate a variety of 6sub