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Synthesis of 6-substituted 2′-deoxyguanosine derivatives using trifluoroacetic anhydride in pyridine

✍ Scribed by Fathi Reza; Goswami Bhaswati; Kung Pei-Pei; Barbara L. Gaffney; Roger A. Jones

Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
291 KB
Volume
31
Category
Article
ISSN
0040-4039

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✦ Synopsis

Trifluoroacetic anhydride at 0" C reacts with a pyridine suspension of deoxyguanosine to generate a polar intermediate, presumably the corresponding 6-pyrldyl derivative. The reaction is complete in less than 15 minutes, and is not accompanied by degradation. From this intermediate a variety of 6substttuted deoxyguanosine derivatives can be obtained, some in excellent yields.

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