Synthesis of O4-p-nitrophenylethyl thymidine and uridine derivatives
β Scribed by Bernd S. Schulz; Wolfgang Pfleiderer
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 188 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
04-Protection
in thymidine and uridine derivatives has been achieved by the p-nitrophenylethyl group in a silver-ion catalysed alkylation reaction to form valuable building blocks for oligonucleotides syntheses.
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A new phosphorylatinq agent, cyclohexylammonium S-phenyl phosphoranilidothioate (2, was prepared in high yield. In this paper, the highly selective deprotection of the phenylthio or anilino group from thymidine 3',5'-diphosphate derivatives masked with the (PhS)2P( 0) and (PhS)(PhNH)P(O) groups is a
## Abstract The 5βmethyl(^15^N~2~)[__O__^2^,__O__^4^β^17^O~2~]uridine (= (^15^N~2~)[__O__^2^,__O__^4^β^17^O ~2~]ribosylthymine; 15) was synthesized and analyzed by ^15^Nβ and ^17^OβNMR spectroscopy. (^15^N~2~)Urea was condensed with 2,3βdibromoβ2βmethylpropanoyl chloride (3) and cyclized to form (^
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