## 04-Protection in thymidine and uridine derivatives has been achieved by the p-nitrophenylethyl group in a silver-ion catalysed alkylation reaction to form valuable building blocks for oligonucleotides syntheses.
Synthesis and Properties of Thymidine Derivatives Bearing the (PhS)2P(O) and (PhS) (PhNH)P(O) groups
β Scribed by Mitsuo Sekine; Tsujiaki Hata
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 255 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A new phosphorylatinq agent, cyclohexylammonium S-phenyl phosphoranilidothioate (2, was prepared in high yield. In this paper, the highly selective deprotection of the phenylthio or anilino group from thymidine 3',5'-diphosphate derivatives masked with the (PhS)2P( 0) and (PhS)(PhNH)P(O) groups is also described.
π SIMILAR VOLUMES
The structure of Ph[PhC(O)NH] 2 PyNC(O)Ph (2) in solid state and in solution is discussed on the basis of a crystal structure analysis and IR and Raman spectra. In crystalline state 2 forms dimers which are associated via two pairs of bifurcated (N-H) 2 β’ β’ β’OyC hydrogen bonds. The spectroscopic dat