✦ LIBER ✦

Synthesis of Novel Thiazolyl-Pyrimidines and Their Anticancer Activity in Vitro

✍ Scribed by Hai-Bo Shi; Hai-Bo Li; Kong-Qin Lu; Xia-Re Zhu; Wei-Xiao Hu; Wen Pei

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 150 KB
Volume: 344
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.201000238

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A series of novel compounds 7–43 were prepared via the condensation of enaminones 4a–h and the guanidines carbonate 6a–f. The structures of these newly synthesized compounds were confirmed by ^1^H‐NMR, MS, EA and IR. All the compounds were tested for their cytotoxic activity in vitro against human cancer cell lines including Ishikawa, A549, BEL‐7404, SPC‐A‐01 and SGC‐7901. Most of them showed moderate cytotoxic against the tested cell lines. Among them, the most potent compounds 9 and 30 exhibited more efficient activity against Ishikawa, A549.

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