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Synthesis of Novel Analogues of 1α,25-Dihydroxyvitamin D 3 with Side Chains at C-18

✍ Scribed by Momán, Edelmiro; Nicoletti, Daniel; Mouriño, Antonio

Book ID: 119953027
Publisher: American Chemical Society
Year: 2004
Tongue: English
Weight: 222 KB
Volume: 69
Category: Article
ISSN: 0022-3263
DOI: 10.1021/jo0498664

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The nuclear hormone 1a,25-dihydroxyvitamin D 3 (1a,25(OH) 2 D 3 ) acts through the transcription factor vitamin D receptor (VDR) via combined contact with the retinoid X receptor (RXR), coactivator proteins, and speci®c DNA binding sites (VDREs). Ligand-mediated conformational changes of the VDR are