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Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D3 analogues with aromatic side chains attached at C-17

✍ Scribed by Liu, Chao; Zhao, Guo-Dong; Mao, Xinliang; Suenaga, Tsutomu; Fujishima, Toshie; Zhang, Cheng-Mei; Liu, Zhao-Peng


Book ID
125858405
Publisher
Elsevier Science
Year
2014
Tongue
French
Weight
881 KB
Volume
85
Category
Article
ISSN
0223-5234

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## Abstract An improved synthetic route to 1α,25‐dihydroxyvitamin D~3~ des‐side chain analogues **2 a** and **2 b** with substituents at C18 is reported, along with their biological activity. These analogues display significant antiproliferative effects toward MCF‐7 breast cancer cells and prodiffe