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Synthesis and Biological Evaluation of 1α,25-Dihydroxyvitamin D 3 Analogues with a Long Side Chain at C12 and Short C17 Side Chains

✍ Scribed by Carballa, Diego M.; Seoane, Samuel; Zacconi, Flavia; Pérez, Xenxo; Rumbo, Antonio; Alvarez-Díaz, Silvia; Larriba, María Jesús; Pérez-Fernández, Román; Muñoz, Alberto; Maestro, Miguel; Mouriño, Antonio; Torneiro, Mercedes


Book ID
115521105
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
683 KB
Volume
55
Category
Article
ISSN
0022-2623

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✍ Dr. Lieve Verlinden; Prof. Annemieke Verstuyf; Dr. Guy Eelen; Prof. Roger Bouill 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 375 KB 👁 1 views

## Abstract An improved synthetic route to 1α,25‐dihydroxyvitamin D~3~ des‐side chain analogues **2 a** and **2 b** with substituents at C18 is reported, along with their biological activity. These analogues display significant antiproliferative effects toward MCF‐7 breast cancer cells and prodiffe