Synthesis of New Xanthene Derivatives with Expected Antischistosomal Activity

✍ Scribed by Zeid, Ibrahim ;El-Kousy, Salah ;El-Torgoman, Abdel Moneim ;Ismail, Abdel Hamid

• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 188 KB
• Volume: 1987
• Category: Article
• ISSN: 0947-3440
• DOI: 10.1002/jlac.198719870210

✦ Synopsis

N-(9H-Xanthen-9-yl)succinimide (1) is prepared by the reaction of xanthene with N-bromosuccinimide. Hydrolysis of 1 with 5% NaOH yields 3-[(9H-xanthen-9-yl)inocarbonyl]propionic acid (3a). The corresponding methyl ester 3c is obtained from 3a by the action of diazomethane. The butanol derivative 4a can be obtained by reduction of 3a or 3c with LiAlH.,. Treatment of 1 with LiAIH, yields the pyrrolidine derivative 5. N-(9H-Xanthen-9-yl)phthalimide (2) undergoes similar reactions like its analogue 1.