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Design and Synthesis of Novel Artemisinin-Like Ozonides with Antischistosomal Activity

✍ Scribed by Zhong-Shun Yang; Wen-Min Wu; Ying Li; Yu-Lin Wu

Publisher: John Wiley and Sons
Year: 2005
Tongue: German
Weight: 105 KB
Volume: 88
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200590229

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

To develop new drugs for prevention and treatment of schistosomiasis, a series of novel artemisinin‐like ozonides 10 were synthesized via a facile three‐step procedure starting with the degraded product of artemisinin (Scheme). The Criegee ozonolysis reaction of the unsaturated lactone intermediates 14 is the key step which provided the target molecules 10. The in vivo pharmacological results suggested that this type of artemisinin analogues exhibited moderate antischistosomal activity (Table).

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