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Synthesis of new phosphonamidate and phosphinamide desmuramyldipeptide analogs

✍ Scribed by Stanislav Gobec; Uroš Urleb

Book ID
110268522
Publisher
Springer Netherlands
Year
1998
Tongue
English
Weight
126 KB
Volume
5
Category
Article
ISSN
1573-3149

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Synthesis and activity of phosphono desmuramyldipeptide analogs
✍ Uroš Urleb; Stanislav Gobec; Dušan Prelog 📂 Article 📅 1995 🏛 Springer Netherlands 🌐 English ⚖ 312 KB

Two phosphono desmuramyldipeptide analogs, 6 and 11, were synthesized and evaluated for immunomodulatory activity. Phthalimido-and adamantyl-substituted side chains as a replacement for the N-acetylmuraminic acid were coupled with appropriate dipeptides using DPPA as the coupling reagent. Introducti