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Synthesis and activity of phosphono desmuramyldipeptide analogs

✍ Scribed by Uroš Urleb; Stanislav Gobec; Dušan Prelog

Publisher
Springer Netherlands
Year
1995
Tongue
English
Weight
312 KB
Volume
2
Category
Article
ISSN
1573-3149

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✦ Synopsis

Two phosphono desmuramyldipeptide analogs, 6 and 11, were synthesized and evaluated for immunomodulatory activity. Phthalimido-and adamantyl-substituted side chains as a replacement for the N-acetylmuraminic acid were coupled with appropriate dipeptides using DPPA as the coupling reagent. Introduction of a phosphonamidate moiety in compound 6 resulted in lower biological activity.

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