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Synthesis and Antidiabetic Activity of 5,7-Dihydroxyflavonoids and Analogs

✍ Scribed by Liu-Shuan Chang; Chun-Bao Li; Nan Qin; Mei-Na Jin; Hong-Quan Duan

Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
198 KB
Volume
9
Category
Article
ISSN
1612-1872

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✦ Synopsis

In a study to evaluate the structural elements essential for the antidiabetic activity of flavonoids, we synthesized two series of flavonoids, 5,7-dihydroxyflavanones and 5,7-dihydroxyflavones. In a screening for potential antidiabetic activity, most of the flavonoids showed a remarkable in vitro activity, and compounds 1f, 2d, and 3c were significantly more effective than the positive control, metformin. The biological activity was mainly affected by structural modification at the ring B moiety of the flavonoid skeleton. The results suggest that 5,7-dihydroxyflavonoids can be considered as promising candidates in the development of new antidiabetic lead compounds.

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